Smad4 Monoclonal Antibody - RA11994

Smad4 Monoclonal Antibody

Size: 50μL, 100μL

Catalogue Numbers: RA11994-50, RA11994-100

Citations, Manuals and MSDS Available upon request.

Background: SMAD family member 4 (SMAD4) Homo sapiens This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE) . The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Oct 2009],

Condition: Ascitic fluid containing 0.03% sodium azide, 0.5% BSA, 50% glycerol.

Storage Instructions: -20°C/1 year

Applications: WB; IHC-p; IF/ICC; FCM; ELISA

Species Cross-Reactivity: Human

GeneID (Human): 4089

SWISS: Q13485

Source: Mouse

Research Use Only