Product Description

SMC1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA12001-50, RA12001-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: structural maintenance of chromosomes 1A (SMC1A) Homo sapiens Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Altern

Reactivity: Human, Mouse, Rat, Pig

Host: Mouse

Applications: WB, IHC-p, IF(paraffin section), FCM

Alternate Names: SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1, Structural maintenance of chromosomes protein 1A, SMC protein 1A, SMC-1-alpha, SMC-1A, Sb1.8

Clonality: Monoclonal

Dilution: Western Blot: 1/1000 - 1/2000. Immunohistochemistry: 1/500 - 1/1000. Flow cytometry: 1/100 - 1/200. Not yet tested in other applications.

Storage: -20°C/1 year

Condition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Human Gene ID: 8243

Research Use Only