SMC1 (Phospho-S957) Polyclonal Antibody-BS94039

SMC1 (Phospho-S957) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS94039-50, BS94039-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q14683(Human) Q8NDV3(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, IHC ICC

All Applications: WB:1:1,000-1:5,000
IHC:1:50-1:200
ICC:1:50-1:200

Background: The SMC (structural maintenance of chromosomes) family of proteins form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation for mitosis. The two distinct classes of SMC protein complexes are comprised of SMC1 (also designated SB1.8) with SMC3 (also designated HCAP for human chromosome-associated protein and Bamacan for the secreted proteoglycan), and SMC2 (also designated hCAP-E) with SMC4 (also designated hCAP-C). The SMC1/SMC3 complex is required for metaphase progression in mitotic cells and functions independently of the SMC2/SMC4 complex during the cell cycle. SMC1 is ubiqitiously expressed in various human tissues, including thymus, testis and colon. SMC3 is expressed as a nuclear protein in the colon, but can also occur as a secreted proteoglycan expressed in testis and brain. The secreted proteoglycan contains several glycosylation sites and is thought to play a role in basement membrane physiology.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: SMC1 (Phospho-S957) polyclonal antibody detects endogenous levels of SMC1 protein only when phosphorylated at S957.

Bioworld Molecular Weight: 160 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of SMC1(phospho S957) on Hela cells lysates using anti- phospho -SMC1(S957) antibody at 1/1,000 dilution., Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti- phospho -SMC1(S957) antibody. Counter stained with hematoxylin.

Alternative Name: SMC protein 1A, SMC-1-alpha, SMC-1A, SMC1A, SMC protein 1B, SMC-1-beta, SMC-1B, SMC1B, CDLS2, DKFZp686L19178, DXhXs423e, DXS423E, KIAA0178, MGC138332, OTTHUMP00000061876, RP6 29D12.1, SB1.8, Segregation of mitotic chromosomes 1, Segregation of mitotic chromosomes like 1, SMC 1, SMC protein 1B, SMC-1-beta, SMC-1B, SMC1, SMC1A, SMC1alpha, SMC1alpha protein, SMC1B, SMC1B, SMC1BETA, SMC1beta protein, SMC1L1, SMC1L2, SMCB, Structural maintenance of chromosome 1 like 1 protein, Structural maintenance of chromosome 1 like 2 protein, Structural maintenance of chromosomes 1A, Structural maintenance of chromosomes 1B, Structural maintenance of chromosomes protein 1B,

Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser957 of human SMC1.

Conjugate: Unconjugated

Modification: Phosphorylation