SMC1 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS91258-50, BS91258-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q14683(Human) Q8NDV3(Human) Q920F6(Mouse) Q9CU62(Mouse) Q9Z1M9(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, ICC/IF, IHC
All Applications: WB:1:1,000-1:2,000
ICC:1:100-1:500
IHC:1:50-1:200
Background: The SMC (structural maintenance of chromosomes) family of proteins form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation for mitosis. SMC1α (structural maintenance of chromosomes protein 1A), also known as SMC1, SMCB, CDLS2, SB1.8, SMC1L1 or DXS423E, is a 1,233 amino acid nuclear protein that is involved in chromosome cohesion during the cell cycle. SMC1α interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role in DNA repair. SMC1α is a component of the cohesion complex, which is required for the cohesion of sister chromatids after DNA replication. Mutations in the gene encoding SMC1α may be the cause of Cornelia de Lange syndrome (CdLS), which is a clinically heterogeneous developmental disorder characterized by facial dysmorphia, upper limb malformations, growth and cognitive retardation.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: SMC1 polyclonal antibody detects endogenous levels of SMC1 protein.
Bioworld Molecular Weight: 143 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of SMC1 on different lysates using anti-SMC1 antibody at 1/1,000 dilution.
Positive control:
Lane 1: NIH/3T3
Lane 2: Hela, ICC staining SMC1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: SMC protein 1A, SMC-1-alpha, SMC-1A, SMC1A, SMC protein 1B, SMC-1-beta, SMC-1B, SMC1B, CDLS2, DKFZp686L19178, DXhXs423e, DXS423E, KIAA0178, MGC138332, OTTHUMP00000061876, RP6 29D12.1, SB1.8, Segregation of mitotic chromosomes 1, Segregation of mitotic chromosomes like 1, SMC 1, SMC protein 1B, SMC-1-beta, SMC-1B, SMC1, SMC1A, SMC1alpha, SMC1alpha protein, SMC1B, SMC1B, SMC1BETA, SMC1beta protein, SMC1L1, SMC1L2, SMCB, Structural maintenance of chromosome 1 like 1 protein, Structural maintenance of chromosome 1 like 2 protein, Structural maintenance of chromosomes 1A, Structural maintenance of chromosomes 1B, Structural maintenance of chromosomes protein 1B,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified