SMC1A Monoclonal Antibody-MB12337

SMC1A Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB12337-50, MB12337-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: Q14683

Host: Mouse

Reactivity: Human

Applications: WB,ICC/IF

All Applications: WB: 1/500-1/1000 IF: 1/50-1/200

Background: Structural maintenance of chromosomes 1 (SMC1) protein is a chromosomal protein member of the cohesin complex that enables sister chromatid cohesion and plays a role in DNA repair . ATM/NBS1-dependent phosphorylation of SMC1 occurs at Ser957 and Ser966 in response to ionizing radiation (IR) as part of the intra-S-phase DNA damage checkpoint. SMC1 phosphorylation is ATM-independent in cells subjected to other forms of DNA damage, including UV light and hydroxyurea treatment.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of SMC1A in K562, Jurkat, C6, 3T3 and HelaLysates using SMC1A antibody.

Bioworld Molecular Weight: Calculated MW: 143 kDa; Observed MW: 143 kDa

Specificity: IgG1

Alternative Name: Chromosome segregation protein SmcB; DXS423E; KIAA0178; MGC138332; Sb1.8; Segregation of mitotic chromosomes 1; SMC protein 1A; SMC-1-alpha; SMC-1A; SMC1 (structural maintenance of chromosomes 1 yeast) like 1; SMC1; SMC1 structural maintenance of chromosomes 1 like 1; SMC1A; SMC1A_HUMAN; SMC1alpha; SMC1L1; SMCB; Structural maintenance of chromosomes 1A; Structural maintenance of chromosomes protein 1A.

Immunogen: Purified recombinant human SMC1A(C-term.) protein fragments expressed in E.coli.

Conjugate: Unconjugated

Modification: Unmodified