SMG7 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-32926-60, E-AB-32926-120, E-AB-32926-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: SMG7
Target Synonym: breast cancer-associated antigen SGA-56M; C1orf16; EST1 like protein C; EST1 telomerase component homolog C; EST1-like protein C; EST1C; ever shorter telomeres 1C; FLJ23717; hSMG-7; nonsense mediated mRNA decay factor (C. elegans); Protein SMG7; SGA56M; SMG 7; SMG-7 homolog; Smg7; SMG7
Research Areas: Epigenetics and Nuclear Signaling
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human
Application: WB, IHC-p, IF, ELISA
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: Q92540
Background: This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.SMG7 (SMG7, Nonsense Mediated MRNA Decay Factor) is a Protein Coding gene. Among its related pathways are Gene Expression and Viral mRNA Translation. GO annotations related to this gene include protein phosphatase 2A binding. An important paralog of this gene is SMG6.
Concentration: 1mg/mL
Immunogen: Synthesized peptide derived from the Internal region of human SMG7
Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Purification Method: Affinity purification
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000
Calculated MW: 127kDa
Observed MW: 127kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only