Product Description

SMPD3 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS71675-50, BS71675-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellμlar functions, such as apoptosis and growth arrest, and is capable of regμlating these 2 cellμlar events independently. Also hydrolyzes sphingosylphosphocholine. Regμlates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regμlator of postnatal development and participates in bone and dentin mineralization. Binds to anionic phospholipids (APLs such as phosphatidylserine (PS and phosphatidic acid (PA that modμlate enzymatic activity and subcellμlar location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity. May act as a mediator in transcriptional regμlation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: SMPD3, NSMASE2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human SMPD3(NP_061137.1).

Dilution: WB, 1:1000 - 1:3000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Polyclonal Antibodies

Molecular Weight: 80kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9NY59

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only