SMYD1 Monoclonal Antibody-MB0166

SMYD1 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB0166-50, MB0166-100

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q8NB12

Host: Mouse

Reactivity: Rat

Applications: WB

All Applications: WB: 1:1000~2000

Background: SMYD1 (SET and MYND domain-containing protein 1), also known as BOP, ZMYND18 or ZMYND22, is a nuclear and cytoplasmic protein that contains one SET domain and one MYND-type zinc finger. Expressed specifically in cardiac and skeletal muscle, SMYD1 functions as a transcription factor that is essential for cardiac morphogenesis and proper cardiomyocyte differentiation. SMYD1 interacts with the histone deacetylases HDAC1, HDAC2 and HDAC3 and, through this interaction, acts as a histone deacetylase-dependent transcriptional repressor. Defects or deletions in the gene encoding SMYD1 lead to retarded maturation of ventricular cardiomyocytes, further implicating SMYD1 as a crucial component of normal cardiac development.

Purification and Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This antibody detects endogenous levels of SMYD1 and does not cross-react with related proteins

Bioworld Molecular Weight: Predicted band size:56KDa
Observed band size:56KDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western BlotDetection of SMYD1 in rat skeletal muscle lysates and using SMYD1 antibody (1:2000 diluted).

Alternative Name: CD8 beta opposite zinc finger; MYND domain containing 18; BOP; KMT3D; ZMYND18; ZMYND22; SMYD1

Immunogen: Recombinant full length Human SMYD1.

Conjugate: Unconjugated

Modification: Unmodified