Product Description

Snail1 (phospho-S246) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4606-50, BS4606-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The Snail family of developmental regμlatory proteins is a group of widely conserved zinc-finger proteins that regμlate transcription and include the mammalian proteins SLUG, SNAI 1, the human homolog of Drosophila SNAIL, and Smuc. SNAI 1 and SLUG are expressed in placenta and adμlt heart, liver, and skeletal muscle. SNAI 1, and the corresponding mouse homolog Sna, each contain three classic zinc fingers and one atypical zinc finger, while SLUG contains five zinc finger regions and a transcriptional repression domain at the amino terminus, which enables SLUG to act as a negative regμlator of gene expression. SLUG is implicated in the generation and migration of neural crest cells in human embryos and also contributes to limb bud development. In addition, SLUG also constitutes a cellμlar anti-apoptotic transcription factor that effectively prevents apoptosis in murine pro-B cells deprived of IL-3.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Zinc finger protein SNAI1, Protein snail homolog 1, Protein sna, SNAI1, SNAH, SNAI 1, Snail 1, Snail-1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic peptide, corresponding to amino acids 211-260 of Human Snail1.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Snail1 (phospho-S246) polyclonal antibody detects endogenous levels of Snail1 protein only when phosphorylated at Ser246.

Molecular Weight: ~ 29 kDa

Pathway: Contribution of Soluble Factors to EMT,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O95863

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only