SNAP25 Polyclonal Antibody
Product: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Sizes: 50µl, 100µl
Catalogue Numbers: BZ16815-50, BZ16815-100
Swiss-Prot: P60880
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, ICC/IF, IP
All Applications: WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
Background: SNAP25 forms a core complex with the SNARE proteins syntaxin and synaptobrevin to mediate synaptic vesicle fusion with the plasma membrane during Ca2+-dependent exocytosis. This complex is responsible for exocytosis of the neurotransmitter γ-aminobutyric acid (GABA). Neurotransmitter release is inhibited by proteolysis of SNAP25 by botulinum toxins A and E. SNAP25 plays a secondary role as a Q-SNARE involved in endosome fusion; the protein is associated with genetic susceptibility to attention-deficit hyperactivity disorder (ADHD).
Purification and Purity: Affinity Purified
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: IgG
Calculated MW: 23 kDa; Observed MW: 23 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of SNAP25 in SH-SY5Y lysates using SNAP25 antibody.
Alternative Name: Synaptosomal-associated protein 25; SNAP-25; Super protein; SUP; Synaptosomal-associated 25 kDa protein; SNAP25; SNAP
Immunogen: A synthesized peptide derived from human SNAP25
Conjugate: Unconjugated
Modification: Unmodified