SnoN rabbit pAb - ES3473

SnoN rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES3473-50, ES3473-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

Alternate Name: SKIL; SNO; Ski-like protein; Ski-related oncogene; Ski-related protein

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human SKIL. AA range:616-665

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 77kD

Human Gene ID: 6498

Human SWISS Prot NO: P12757

Subcellular Location: acrosomal vesicle, nucleus, nucleoplasm, transcription factor complex, cytoplasm, PML body, transcriptional repressor complex, protein complex,

Research Use Only