SOAT1 Polyclonal Antibody-BS8121

SOAT1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS8121-50, BS8121-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P35610

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IF

All Applications: WB 1:500 - 1:2000 IF 1:50 - 1:200

Background: SOAT1 (sterol O-acyltransferase-1), also designated ACAT1, is a homotetra-meric enzyme that catalyzes the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A (acyl-CoA). The gene encoding human SOAT1 maps to chromosome 1 and is expressed as a protein that localizes to the endoplasmic reticulum (ER) in several tissues, including liver, kidney, adrenal glands and macrophages. SOAT1 is involved in cellular cholesterol homeostasis as well as in foam cell formation and the subsequent progression of atherosclerosis. Several SOAT inhibitors have been developed for the treatment of atherosclerosis. SOAT2 (sterol O-acyltransferase-2), also known as ACAT2 (acyl-CoA:cholesterol acyltransferase-2), participates in lipo-protein assembly, catalyzing cholesterol esterification in mammalian cells. SOAT2 is an integral membrane protein that localizes to the endoplasmic reticulum of human intestinal cells. SOAT2 deficiency contributes to severe mental retardation and hypotonus.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SOAT1 polyclonal antibody detects endogenous levels of SOAT1 protein.

Bioworld Molecular Weight: ~ 55 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot (WB) analysis of SOAT1 polyclonal antibody

Alternative Name: Sterol O-acyltransferase 1; Acyl-coenzyme A:cholesterol acyltransferase 1; ACAT-1; Cholesterol acyltransferase 1; SOAT1; ACACT; ACACT1; ACAT; ACAT1; SOAT; STAT

Immunogen: Recombinant full length Human SOAT1.

Conjugate: Unconjugated

Modification: Unmodified