Product Description

SOCS-3 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA20758-50, RA20758-100

Citations, Manuals and MSDS Available upon request.

Background: suppressor of cytokine signaling 3 (SOCS3) Homo sapiens This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN) -gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: Western Blot: 1/500 - 1/2000.IHC-p:1:50-300. Not yet tested in other applications.

Alternative Names: Suppressor of cytokine signaling 3 (SOCS-3;Cytokine-inducible SH2 protein 3;CIS-3;STAT-induced STAT inhibitor 3;SSI-3)

Applications: WB; IHC-p; IF (paraffin section)

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 9021

SWISS: O14543

Source: Rabbit

Research Use Only