Product Description

SOCS7 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65853-50, BS65853-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regμlates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS1 and SOCS6 interact with the insμlin receptor (IR) when expressed in human hepatoma cells (HepG2) or in rat hepatoma cells overexpressing human IR. SOCS1 and SOCS6 inhibit insμlin-dependent activation of ERK1/2 and protein kinase B in vivo and IR- directed phosphorylation of IRS1 in vitro. These resμlts suggest that SOCS proteins may be inhibitors of IR signalling and coμld mediate cytokine-induced insμlin resistance and contribute to the pathogenesis of type II diabetes. SOCS6 and SOCS7 are expressed ubiquitously in murine tissues and SOCS6 knockout mice are growth retarded.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Rabbit

Host: Rabbit

Applications: WB

Alternate Names: NAP 4, NAP 4 Fragment, NAP4, Nck Ash and phospholipase C binding protein, Nck Ash and phospholipase C gamma binding protein, Nck associated protein 4, NCKAP4, SH2 domain containing SOCS box protein, SOCS 7, SOCS4, SOCS6, Suppressor of cytokine signaling 7, SOCS7_HUMAN.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human SOCS7:171-270/581

Dilution: WB=1:500-2000

Purification: affinity purified by Protein A

Specificity: SOCS7 Polyclonal Antibody detects endogenous levels of SOCS7 protein.

Molecular Weight: ~60kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -26°C long term. Avoid freeze-thaw cycles.

SwissProt: O14512

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only