Product Description

SORCS2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS65710-50, BS65710-100

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Swiss-Prot: Q96PQ0

Host: Rabbit

Reactivity: Human, Mouse, Rat,

Applications: WB

All Applications: WB=1:500-2000

Background: There are three SorCS genes that have diverse, partially overlapping functions in the central nervous system. In the developing and mature central nervous system, SorCS1, SorCS2 and SorCS3 genes are expressed in a combinatorial, non-overlapping pattern. SorCS proteins show homology to the mosaic receptor SorLA and the neurotensin receptor sortilin, based on a common VPS10 domain, which is the hallmark of the SorCS receptor family. SorCS2 (sortilin-related VPS10 domain containing receptor 2) is a 1,150 amino acid single-pass type I membrane protein that is highly expressed in brain and kidney. Containing six BNR repeats and a single PKD domain, SorCS2 is encoded by a gene that maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.

Purification and Purity: affinity purified by Protein A

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SORCS2 Polyclonal Antibody detects endogenous levels of SORCS2 protein.

Bioworld Molecular Weight: 123kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Primary: Anti- SORCS2 at 1/1000 dilution

Alternative Name: KIAA1329; SORCS 2; Sortilin related VPS10 domain containing receptor 2; VPS10 domain receptor protein; VPS10 domain receptor protein SORCS 2; SORC2_HUMAN.

Immunogen: KLH conjugated synthetic peptide derived from human SORCS2:201-300/1159

Conjugate: Unconjugated

Modification: Unmodified