Sox2 (phospho-Ser250/Ser251) rabbit pAb - ES13010

Sox2 (phospho-Ser250/Ser251) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES13010-50, ES13010-100

Citations, Manuals and MSDS Available upon request.

Background: SRY-box 2 (SOX2) Homo sapiens This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008],

Alternate Name: Transcription factor SOX-2

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Mouse

Immunogen: Synthesized phosho peptide around human Sox2 (Ser250 and Ser251)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 35kD

Human Gene ID: 6657

Human SWISS Prot NO: P48431

Subcellular Location: Nucleus speckle. Cytoplasm. Nucleus. Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity).

Research Use Only