SPAG1 Polyclonal Antibody - E-AB-15858

SPAG1 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-15858-60, E-AB-15858-120, E-AB-15858-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: SPAG1

Target Synonym: CILD28; FLJ32920; HSD-3.8; Infertility related sperm protein Spag 1; SP75; SPAG1; Sperm associated antigen 1; Tetratricopeptide repeat-containing protein; TPIS; TPR containing protein involved in spermatogenesis

Research Areas: Developmental Biology

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: WB, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q07617

Background: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.

Concentration: 0.3 mg/mL

Immunogen: Synthetic peptide of human SPAG1

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000

Calculated MW: 104kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only