Spectrin β II rabbit pAb - ES7262

Spectrin β II rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES7262-50, ES7262-100

Citations, Manuals and MSDS Available upon request.

Background: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Alternate Name: SPTBN1; SPTB2; Spectrin beta chain; non-erythrocytic 1; Beta-II spectrin; Fodrin beta chain; Spectrin, non-erythroid beta chain 1

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human SPTBN1. AA range:651-700

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 275kD

Human Gene ID: 6711

Human SWISS Prot NO: Q01082

Subcellular Location: Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, M line. Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes.; [Isoform 2]: Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Research Use Only