Splicing factor 1 Polyclonal Antibody - RA29999

Splicing factor 1 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA29999-50, RA29999-100 Citations, Manuals and MSDS Available upon request. Background: splicing factor 1 (SF1) Homo sapiens This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016], Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. Alternative Names: SF1; ZFM1; ZNF162; Splicing factor 1; Mammalian branch point-binding protein; BBP; mBBP; Transcription factor ZFM1; Zinc finger gene in MEN1 locus; Zinc finger protein 162 Applications: WB; IHC-p; IF/ICC; ELISA Species Cross-Reactivity: Human; Mouse GeneID (Human): 7536 Protein MW (KDa): 68 SWISS: Q15637 Source: Rabbit Research Use Only