SPOP Polyclonal Antibody - BT-AP08515

SPOP Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP08515-20, BT-AP08515-50, BT-AP08515-100

Citations, Manuals and MSDS Available upon request.

Background: SPOP (speckle type BTB/POZ protein) encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1. , a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of SPOP results in multiple transcript variants encoding the same protein.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: SPOP

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: SPOP Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 42132

UniProt Accession: Human: O43791; Mouse: Q6ZWS8

Synonyms: Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)

GeneID: Human: 8405; Mouse: 20747

Research Use Only