SPOP rabbit pAb - ES8522

SPOP rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8522-50, ES8522-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],

Alternate Name: Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human SPOP. AA range:41-90

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 42kD

Human Gene ID: 8405

Human SWISS Prot NO: O43791

Subcellular Location: Nucleus. Nucleus speckle.

Research Use Only