SPRY2 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A1855-20, A1855-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.
Category: Polyclonal Antibodies
Applications: WB, IHC-P, ELISA
Cross-reactivity: Human, Mouse
Protein Weight: 35kDa
Observed Molecular Weight: 38kDa
Immunogen: Synthetic peptide .
Species: Human
GeneID: 10253
SWISS: O43597
Alternate Names: IGAN3; hSPRY2; SPRY2
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 IHC-P, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction, ErbB-HER Signaling Pathway, MAPK-Erk Signaling Pathway, Neuroscience, Stem Cells, Mesenchymal Stem Cells, Cardiovascular, Angiogenesis.
NCBI Alias: SPRY2
Research Use Only