SPTLC1 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS8409-50, BS8409-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: O15269
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, IHC
All Applications: WB: 1:500~1:2000
IHC: 1:50~1:200
Background: SPTLC1 (serine palmitoyltransferase 1), also known as LCB1, and SPTLC2 (serine palmitoyltransferase 2), also known as LCB2, together catalyze sphingolipid biosynthesis by converting L-serine and palmitoyl-CoA to 3-oxosphinganine, utilizing pyridoxal 5'-phosphate as a cofactor. Increases in transepidermal water loss triggers upregulation of serine palmitoyltransferase mRNA expression in humans. Deficiencies in wild type SPTLC1 and SPTLC2 can lead to hereditary sensory neuropathy, atopic eczema, and psoriasis.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: SPTLC1 polyclonal antibody detects endogenous levels of SPTLC1 protein.
Bioworld Molecular Weight: ~ 53 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western Blot (WB) analysis of SPTLC1 polyclonal antibody
Alternative Name: Serine palmitoyltransferase 1; Long chain base biosynthesis protein 1; LCB 1; Serine-palmitoyl-CoA transferase 1; SPT 1; SPT1; SPTLC1; LCB1
Immunogen: Recombinant full length Human SPTLC1.
Conjugate: Unconjugated
Modification: Unmodified