SPTN2 rabbit pAb - ES12970

SPTN2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES12970-50, ES12970-100

Citations, Manuals and MSDS Available upon request.

Background: Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009],

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Rat

Immunogen: Synthesized peptide derived from human SPTN2 AA range: 644-694

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 6712

Human SWISS Prot NO: O15020

Subcellular Location: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.

Research Use Only