Product Description

SR-1E (A127) Polyclonal Antibody

Catalogue Numbers:BS2386-50, BS2386-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P28566

Host: Rabbit

Reactivity: Human

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: The members of the G protein-coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. β-adrenergic bound to adrenaline activates adenylyl cyclase, while α2-adrenergic receptor bound to adrenaline inhibits adenylyl cyclase. Like the α2-adrenergic receptor, serotonin receptor functions are also mediated by G proteins that inhibit the activity of adenylyl cyclase. The serotonin receptors have been classified into several categories, designated SR-1–7 (5HT1–7). Subtypes within the SR-1 group include SR-1A, -1B, -1D, -1E and -1F.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Bioworld Molecular Weight: ~ 42 kDa

Specificity: SR-1E (A127) polyclonal antibody detects endogenous levels of SR-1E protein.

Note: For research use only, not for use in diagnostic procedure.
Alternative Name: HTR1E; 5-hydroxytryptamine receptor 1E; Serotonin receptor 1E; 5-HT-1E; 5-HT1E

Immunogen: Synthetic peptide, corresponding to amino acids 95-140 of Human SR-1E.

Conjugate: Unconjugated

Modification: Unmodified