Product Description

SSB (phospho-S366) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: AP0349-50, AP0349-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Ro/SSA is a ribonucleoprotein that binds to autoantibodies in 35 to 50% of patients with SLE and in up to 97% of patients with Sjogren syndrome. The Ro/SSA particle consists of a single immunoreactive protein noncovalently bound with one of four small RNA molecμles. Most anti-Ro/SSA-positive sera have antibodies not only against the immunoreactive protein, but also against an Ro/SSA protein. The genes which encode the two proteins map to human chromosomes 11p15.5 and 1q31, respectively. La/SSB is an autoimmune RNA-binding protein that plays a role in the transcription of RNA polymerase III was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and SLE.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB

Alternate Names: Autoantigen La, La, La autoantigen, La autoantigen homolog, La protein, La ribonucleoprotein, La ribonucleoprotein domain family member 3, LA, LARP3, Lupus La antigen, Lupus La protein, Lupus La protein homolog, mRNA for autoantigen, Sjoegren syndrome type B antigen, Sjoegren syndrome type B antigen, Sjogren syndrome antigen B, SS B, SS-B, SS-B/La protein, SSB,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human SSB around the phosphorylation site of Serine 366.

Dilution: WB: 1:1000~1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 110% (by SDS-PAGE).

Specificity: p-SSB (S366) polyclonal antibody detects endogenous levels of SSB protein only when phosphorylated at Serine 366.

Molecular Weight: ~ 52 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P05455

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only