Product Description

SSB (T362) Polyclonal Antibody

Catalogue Numbers: AP0467-50, AP0467-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P05455

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:1000~1:2000

Background: Ro/SSA is a ribonucleoprotein that binds to autoantibodies in 35 to 50% of patients with SLE and in up to 97% of patients with Sjogren syndrome. The Ro/SSA particle consists of a single immunoreactive protein noncovalently bound with one of four small RNA molecules. Most anti-Ro/SSA-positive sera have antibodies not only against the immunoreactive protein, but also against an Ro/SSA protein. The genes which encode the two proteins map to human chromosomes 11p15.5 and 1q31, respectively. La/SSB is an autoimmune RNA-binding protein that plays a role in the transcription of RNA polymerase III was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and SLE.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 110% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SSB(T362) polyclonal antibody detects endogenous levels of SSB protein.

Extra Notes: Western blot (WB) analysis of SSB (T362) polyclonal antibody at 1:1000 dilution
Lane1:HEK293T whole cell lysate(40ug)
Lane2:L02 whole cell lysate(40ug)
Lane3:SK-OVCAR3 whole cell lysate(40ug)
Lane4:MCF-7 whole cell lysate(40ug)
Lane5:HepG2 whole cell lysate(40ug)
Lane6:A549 whole cell lysate(40ug)

Bioworld Molecular Weight: ~ 52 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Autoantigen La; La; La autoantigen; La autoantigen homolog; La protein; La ribonucleoprotein; La ribonucleoprotein domain family member 3; LA; LARP3; Lupus La antigen; Lupus La protein; Lupus La protein homolog; MGC118101; MGC93380; mRNA for autoantigen; OTTMUSP00000014043; RP23 273G23.1; Sjoegren syndrome type B antigen; Sjoegren syndrome type B antigen; Sjogren syndrome antigen B (autoantigen La); Sjogren syndrome antigen B; SS B; SS-B; SS-B/La protein; SSB;

Immunogen: Synthetic peptide, corresponding to amino acids 331-380 of Human SSB.

Conjugate: Unconjugated

Modification: Unmodified