SSB (T362) Polyclonal Antibody-BS1770

SSB (T362) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS1770-50, BS1770-100

Sizes: 50µl, 100µl

Swiss-Prot: P05455

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: Ro/SSA is a ribonucleoprotein that binds to autoantibodies in 35 to 50% of patients with SLE and in up to 97% of patients with Sjogren syndrome. The Ro/SSA particle consists of a single immunoreactive protein noncovalently bound with one of four small RNA molecules. Most anti-Ro/SSA-positive sera have antibodies not only against the immunoreactive protein, but also against an Ro/SSA protein. The genes which encode the two proteins map to human chromosomes 11p15.5 and 1q31, respectively. La/SSB is an autoimmune RNA-binding protein that plays a role in the transcription of RNA polymerase III was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and SLE.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: SSB (T362) polyclonal antibody detects endogenous levels of SSB protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of SSB (T362) pAb at 1:1000 dilution
Lane 1: A2780 whole cell lysate (20ug)
Lane 2: PC3 whole cell lysate (20ug)
Lane 3: L02 whole cell lysate (20ug)
Lane 4: The Ovary tissue lysate of Rat (40ug)
Lane 5: AML-12 whole cell lysate (40ug)
Lane 6: 3T3-L1 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of SSB (T362) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~50 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Autoantigen La; La; La autoantigen; La autoantigen homolog; La protein; La ribonucleoprotein; La ribonucleoprotein domain family member 3; LA; LARP3; Lupus La antigen; Lupus La protein; Lupus La protein homolog; MGC118101; MGC93380; mRNA for autoantigen; OTTMUSP00000014043; RP23 273G23.1; Sjoegren syndrome type B antigen; Sjoegren syndrome type B antigen; Sjogren syndrome antigen B (autoantigen La); Sjogren syndrome antigen B; SS B; SS-B; SS-B/La protein; SSB;

Immunogen: Synthetic peptide, corresponding to amino acids 331-380 of Human SSB.

Conjugate: Unconjugated

Modification: Unmodified