SSRP1 rabbit pAb - ES12943

SSRP1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES12943-50, ES12943-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008],

Source: Rabbit

Applications: WB

Dilution: WB 1: 500-2000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human SSRP1 AA range: 209-259

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 6749

Human SWISS Prot NO: Q08945

Subcellular Location: Nucleus. Nucleus, nucleolus. Chromosome. Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.

Research Use Only