Stat3 Monoclonal Antibody
Sizes: 50μL, 100μL
Catalogue Number: BT-MCA1162-50, BT-MCA1162-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper
Research Areas: Signal transduction; Epigenetics and nuclear signaling; Cancer; Microbiology; Stem cells; Cardiovascular; Developmental biology
Target Protein: STAT3
Applications: WB, IHC-p, IF, ELISA
Reactivity: Human
Clonality: Monoclonal
Host: Mouse
Isotype: IgG
Full Product Name: Signal transducer and activator of transcription 3
Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189
Storage: -20°C for 1 year
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration: 1 mg/ml
UniProt Accession: Human: P40763; Mouse: P42227
Synonyms: STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor
GeneID: Human: 6774
Research Use Only