Stat4 (phospho Tyr693) rabbit pAb - ES1407

Stat4 (phospho Tyr693) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES1407-50, ES1407-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011],

Alternate Name: STAT4; Signal transducer and activator of transcription 4

Source: Rabbit

Applications: WB; IHC; IF; IP; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/5000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat; Monkey

Immunogen: The antiserum was produced against synthesized peptide derived from human STAT4 around the phosphorylation site of Tyr693. AA range:660-709

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 86kD

Human Gene ID: 6775

Human SWISS Prot NO: Q14765

Subcellular Location: Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.

Research Use Only