Stat5 (Phospho-Tyr694) Rabbit Polyclonal Antibody - BT-AP12838

Stat5 (Phospho-Tyr694) Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP12838-20, BT-AP12838-50, BT-AP12838-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors| STAT family members are phosphorylated by the receptor associated kinases| and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands| such as IL2| IL4| CSF1| and different growth hormones. It has been shown to be involved in diverse biological processes| such as TCR signaling| apoptosis| adult mammary gland development| and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Research Areas: Epigenetics and nuclear signaling; Cancer; Signal transduction; Metabolism

Target Protein: STAT5B

Applications: WB

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Stat5

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P51692; Mouse: P42232; Rat: P52632

Synonyms: Stat5;Tyr694; Signal transducer and activator of transcription 5B

GeneID: Human: 6777; Mouse: 20851; Rat: 25126

Research Use Only