Product Description

STAT5b Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA35084-50, RA35084-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: signal transducer and activator of transcription 5B (STAT5B) Homo sapiens The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provi

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, IHC-p, IF (paraffin section)

Alternate Names: Signal transducer and activator of transcription 5B, YM3465

Clonality: Polyclonal

Dilution: WB: 1:500-1:2000 IHC: 1:50-1:200

Molecular Weight: 90

Protein Molecular Weight (kDa): 90

Storage: -20°C/1 year

Human Gene ID: 6777

Human SwissProt Number: P51692

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only