Stat6 (phospho Thr645) rabbit pAb - ES1408

Stat6 (phospho Thr645) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES1408-50, ES1408-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],

Alternate Name: STAT6; Signal transducer and activator of transcription 6; IL-4 Stat

Source: Rabbit

Applications: WB; IHC; IF; IP; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human STAT6 around the phosphorylation site of Thr645. AA range:612-661

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 6778

Human SWISS Prot NO: P42226

Subcellular Location: Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.

Research Use Only