STAT6 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A0755-20, A0755-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
Category: Polyclonal Antibodies
Applications: WB, IF/ICC, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 94kDa
Observed Molecular Weight: 110kDa
Immunogen: Synthetic peptide
Species: Human
GeneID: 6778
SWISS: P42226
Alternate Names: STAT6B; STAT6C; D12S1644; IL-4-STAT; STAT6
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Protein phosphorylation, Signal Transduction, Immunology Inflammation, Jak-Stat-IL-6 Receptor Signaling Pathway.
NCBI Alias: STAT6
Research Use Only