STAT6 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A24832-20, A24832-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Human
Protein Weight: 74kDa/81kDa/94kDa
Observed Molecular Weight: 94kDa
Immunogen: Synthetic peptide .
Species: Human
GeneID: 6778
SWISS: P42226
Alternate Names: STAT6; D12S1644; IL-4-STAT; STAT6B; STAT6C; signal transducer and activator of transcription 6
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:1000 - 1:5000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics & Nuclear Signaling, Transcription Factors, Signal Transduction, Immunology & Inflammation, IL-6 Receptor Signaling Pathway.
NCBI Alias: STAT6
Research Use Only