Staufen Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS91295-50, BS91295-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: O95793(Human) Q9Z108(Mouse)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, ICC/IF FC
All Applications: WB:1:500-1:2,000
ICC/IF:1:50-1:200
FC:1:50-1:100
Background: STAU1 (staufen, RNA binding protein, homolog 1) is a 577 amino acid protein that contains three double-stranded RNA-binding domains and is a mammalian homolog of Staufen, a Drosophila protein that is involved in mRNA transport during oogenesis and zygotic development. Localized to the rough endoplasmic reticulum (RER) and expressed in a variety of tissues, including heart, brain, liver, lung, pancreas, kidney and placenta, STAU1 binds to both Tubulin and double-stranded RNA and is thought to play an important role in mRNA transport from the microtubule network to the RER. Additionally, STAU1 may be involved in cross-linking cytoskeletal components with RNA, an event that is important for proper mRNA positioning during translation. Alternative splicing of the STAU1 gene yields two STAU1 isoforms, designated short and long.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Staufen polyclonal antibody detects endogenous levels of Staufen protein.
Bioworld Molecular Weight: 63 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of Staufen on K562 cell using anti-Staufen antibody at 1/1,000 dilution., ICC staining Staufen in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: STAU1, STAU, Double stranded RNA binding protein Staufen homolog 1, Double stranded RNA binding protein Staufen homolog, Double-stranded RNA-binding protein Staufen homolog 1, FLJ25010, MGC124588, PPP1R150, STAU, STAU1, STAU1, staufen, Staufen RNA binding protein (Drosophila), Staufen RNA binding protein homolog 1, Staufen, Drosophila, homolog of, 1, Staufen, RNA binding protein, homolog 1 (Drosophila), staufen-like,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodified