STK3 Monoclonal Antibody-MB11644

STK3 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11644-50, MB11644-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q13188

Host: Rabbit

Reactivity: Human, Mouse, Rat, Hamster

Applications: WB, IHC-P, IP,

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20

Background: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 56 kDa; Observed MW: 56 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of STK3/MST2 in 3T3, Raw264.7 lysates using STK3 antibody., Western blot analysis of STK3/MST2 in CHO-K1, C6, Jurkat lysates using STK3/MST2 antibody., Immunohistochemistry analysis of paraffin-embedded Human lung cancer using STK3 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Alternative Name: STK3; Mess1; MST-2; MST2; Serine/threonine kinase 3; KRS1; STE20-like kinase MST2

Immunogen: A synthetic peptide of human STK3

Conjugate: Unconjugated

Modification: Unmodified