Sugen Kinase 269 Polyclonal Antibody-BS62506

Sugen Kinase 269 Polyclonal Antibody

Catalogue Numbers: BS62506-50, BS62506-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9H792

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB

All Applications: WB:1:500~1:1000

Background: PEAK1 (Pseudopodium-enriched atypical kinase 1 or sgk269) is a member of nonreceptor atypical tyrosine kinase family identified by MS analysis of purified psedopodium. PEAK1 is a multi-domain protein with a N-terminal Erk binding site, followed by actin-targeting/Src substrate/Erk substrate region, Crk binding site, Shc binding site, and a C-terminal kinase domain. By interacting with different adaptors like Shc, Grb2, Src, and others, PEAK1 functions as an important regulator in different signaling pathways, namely the Src/PEAK1/ErbB2, EGFR Shc1/PEAK1/Grb2, TGFβ/PEAK1/Src/MAPK, and fibronectin/PEAK1/Src pathways. PEAK1 plays an instrumental role in a wide variety of biological processes including epithelial-mesenchymal transition (EMT), dynamics of focal adhesion, cancer metastatic growth and invasion as well as cancer drug resistance. Phosphorylation of PEAK1 at Tyr665 or Tyr635 by SFK (Src family Kinases) has been shown to be essential for cancer cell migration and invasion as well as the turnover of focal adhesions.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Sugen Kinase 269 polyclonal antibody detects endogenous levels of Sugen Kinase 269 protein.

Extra Notes: Western blot (WB) analysis of Sugen Kinase 269 polyclonal antibody at 1:500 dilution
LaneA:HEK293T whole cell lysate
LaneB:L02 whole cell lysate

Bioworld Molecular Weight: ~ 193 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Inactive tyrosine-protein kinase PEAK1; Pseudopodium-enriched atypical kinase 1; Sugen kinase 269; Tyrosine-protein kinase SgK269; PEAK1; KIAA2002

Immunogen: Synthetic peptide, corresponding to Human Sugen Kinase 269.

Conjugate: Unconjugated

Modification: Unmodified