Product Description

SUN1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS9956M-50, BS9956M-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O94901

Host: Rabbit

Reactivity: Human, Rat

Applications: WB, IHC ICC FC

All Applications: WB: 1:500-1:2000 IHC: 1:50-1:200
ICC: 1:50-1:200 FC: 1:50-1:100

Background: UNC84A (UNC84 homolog A), also known as SUN1, is a multi-pass nuclear membrane protein that is involved in nuclear anchoring and migration. Highly expressed in heart, brain and testis, UNC84A functions as an A-type Lamin-binding protein that forms a link between the inner and outer nuclear envelope membranes. This link acts as a structural bridge between the nuclear interior and the Actin cytoskeleton and is essential for proper localization of nuclear envelope proteins. Additionally, UNC84A may be involved in telomere attachment and in normal testis development. UNC84A contains one UNC84 (SUN) domain and exists as four isoforms due to alternative splicing events.

Purification and Purity: Protein A affinity purified.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This antibody detects endogenous levels of SUN1 and does not cross-react with related proteins.

Bioworld Molecular Weight: ~ 90 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of SUN1 on rat kidney tissue lysate using anti-SUN1 antibody at 1:2000 dilution., Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-SUN1 antibody. Counter stained with hematoxylin., Flow cytometric analysis of SH-SY-5Y cells with SUN1 antibody at 1/100 dilution (purple) compared with an unlabelled control (cells without incubation with primary antibody; yellow). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.

Alternative Name: SUN domain-containing protein 1; Protein unc-84 homolog A; Sad1/unc-84 protein-like 1; SUN1; KIAA0810; UNC84A

Immunogen: Recombinant protein corresponding to C-terminal human SUN1.

Conjugate: Unconjugated

Modification: Unmodified