Product Description

SUR1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65637-50, BS65637-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: SUR1 is a member of ATP binding cassette super family. SUR receptor confers the sensitivity of Kir6.2 to ATP/ADP sensitivity and to pharmacological agents such as sμlfonylurea and diazoxide that close or open the KATP channels. The persistent heyperinsμlinimic hypoglycemia in infancy (PHHI) is familial disorder due to defect in negative feed back in response to low glucose levels. SUR1 was mapped on chromosome 11p14-15.1, the same location where the gene for PHHI is located. It has been shown that the expression of Kir6.2 and SUR1 are regμlated by glucose levels and the actives of glucogon like peptide receptor 1. Abnormal insμlin secretion in PHHI appears to be caused by mutations in the SUR gene.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Dog, Pig, Horse, Guinea Pig

Host: Rabbit

Applications: WB

Alternate Names: ABC36, Abcc8, ATP binding cassette sub family C (CFTR/MRP) member 8, ATP binding cassette transporter sub family C member 8 (1), HHF1, HRINS, MRP8, PHHI, Sμlfonylurea receptor 1, SUR.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human SUR1

Dilution: WB=1:500-2000

Purification: affinity purified by Protein A

Specificity: SUR1 Polyclonal Antibody detects endogenous levels of SUR1 protein.

Molecular Weight: 175 kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q09428

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only