SUR1 Polyclonal Antibody-BS65637

SUR1 Polyclonal Antibody

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Sizes: 50µl, 100µl

Catalogue Numbers: BS65637-50, BS65637-100

Swiss-Prot: Q09428

Host: Rabbit

SUR1 Polyclonal Antibody-BS65637

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Reactivity: Human, Mouse, Rat, Dog, Pig, Horse, Guinea Pig,

Applications: WB,

All Applications: WB=1:500-2000

Background: SUR1 is a member of ATP binding cassette super family. SUR receptor confers the sensitivity of Kir6.2 to ATP/ADP sensitivity and to pharmacological agents such as sulfonylurea and diazoxide that close or open the KATP channels. The persistent heyperinsulinimic hypoglycemia in infancy (PHHI) is familial disorder due to defect in negative feed back in response to low glucose levels. SUR1 was mapped on chromosome 11p14-15.1, the same location where the gene for PHHI is located. It has been shown that the expression of Kir6.2 and SUR1 are regulated by glucose levels and the actives of glucogon like peptide receptor 1. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene.

Purification and Purity: affinity purified by Protein A

Specificity: SUR1 Polyclonal Antibody detects endogenous levels of SUR1 protein.

Bioworld Molecular Weight: 175 kD

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Sample:
Hippocampus (Mouse) Lysate at 40 ug
Primary: Anti-SUR1 at 1/1000 dilution, Sample:
Cerebellum (Mouse) Lysate at 40 ug
Primary: Anti- SUR1 at 1/1000 dilution

Alternative Name: ABC36; Abcc8; ATP binding cassette sub family C (CFTR/MRP) member 8; ATP binding cassette transporter sub family C member 8 (1); HHF1; HRINS; MRP8; PHHI; Sulfonylurea receptor 1; SUR.

Immunogen: KLH conjugated synthetic peptide derived from human SUR1

Modification: Unmodified

Conjugate: Unconjugated