Product Description

Survivin (N111) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1771-50, BS1771-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Two mammalian homologs of bacμlovirus p35, referred to as inhibitor of apoptosis protein (IAP) 1 and 2, share an amino-terminal bacμlovirus IAP repeat (BIR) motif and a carboxy-terminal RING finger. Although the c-IAPs do not directly associate with the TNF receptor (TNF-R), they efficiently block TNF-mediated apoptosis through their interaction with the downstream TNF-R effectors, TRAF1 and TRAF2. Additional IAP family members include ILP (for IAP-like protein) and survivin. ILP inhibits activated caspase-3, leading to the resistance of FASmediated apoptosis. Survivin (also designated TIAP) is expressed during the G2/M phase of the cell cycle and associates with microtubμles of the mitotic spindle. Increased caspase-3 activity is detected when a disruption of survivinmicrotubμle interactions occurs.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF

Alternate Names: Survivin, Apoptosis inhibitor survivin, Apoptosis inhibitor 4, BIRC5, API4, IAP4

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 81-130 of Human Survivin.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Survivin (N111) polyclonal antibody detects endogenous levels of Survivin protein.

Molecular Weight: ~ 16 kDa

Pathway: Regμlation of Apoptosis, Epigenetic Writers and Erasers of Histone H3,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O15392

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only