Survivin Rabbit Monoclonal Antibody-BS9870M

Survivin Rabbit Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS9870M-50, BS9870M-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O70201

Host: Rabbit

Reactivity: Mouse, Rat

Applications: WB, IHC

All Applications: WB: 1:1000-1:2000
IHC: 1:50-1:200

Background: Two mammalian homologs of baculovirus p35, referred to as inhibitor of apoptosis protein (IAP) 1 and 2, share an amino-terminal baculovirus IAP repeat (BIR) motif and a carboxy-terminal RING finger. Although the c-IAPs do not directly associate with the TNF receptor (TNF-R), they efficiently block TNF-mediated apoptosis through their interaction with the downstream TNF-R effectors, TRAF1 and TRAF2. Additional IAP family members include ILP (for IAP-like protein) and survivin. ILP inhibits activated caspase-3, leading to the resistance of FASmediated apoptosis. Survivin (also designated TIAP) is expressed during the G2/M phase of the cell cycle and associates with microtubules of the mitotic spindle. Increased caspase-3 activity is detected when a disruption of survivinmicrotubule interactions occurs.

Purification and Purity: Protein A affinity purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This antibody detects endogenous levels of Survivin and does not cross-react with related proteins.

Bioworld Molecular Weight: ~ 16 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Survivin Rabbit mAb at 1:1000 dilution
Lane 1: L929 whole cell lysate
Lane 2: F9 whole cell lysate, Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-Survivin antibody. Counter stained with hematoxylin.

Alternative Name: Survivin; Apoptosis inhibitor survivin; Apoptosis inhibitor 4; BIRC5; API4; IAP4

Immunogen: Recombinant antibody.

Conjugate: Unconjugated

Modification: Unmodified