Product Description

SWAP-70 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66544-50, MB66544-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: SWAP70 is a Rac family guanine nucleotide exchange factor (GEF). It is highly expressed by activated B cells. Following B cell stimμlation, SWAP70 has been observed to translocate from the cytoplasm to the nucleus, where it plays a role in class switching, as well as to the membrane, where it associates with the B cell receptor. SWAP70 also plays a role in migration of B cells and other immune cell types including dendritic cells, eosinophils, and mast cells. Mice deficient in both SWAP70 and a related protein, DEF6, develop lupus-like autoimmunity due to misregμlation of IRF4 in B cells and T cells leading to increased IL21 production and responsiveness.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Monkey

Host: Mouse

Applications: WB, IP

Alternate Names: KIAA0640, Switch-associated protein 70, SWAP-70

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Purified recombinant human SWAP70 protein fragments expressed in E.coli.

Dilution: WB (1/500 - 1/1000), IP (1/10 - 1/50)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of SWAP-70 protein.

Molecular Weight: ~ 65 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UH65

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only