SWAP-70 Monoclonal Antibody-MB66544

SWAP-70 Monoclonal Antibody

Catalogue Numbers: MB66544-50, MB66544-100

Sizes: 50µl, 100µl

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: Q9UH65

Host: Mouse

Reactivity: Human, Mouse, Rat, Monkey

Applications: WB, IP

All Applications: WB (1/500 - 1/1000), IP (1/10 - 1/50)

Background: SWAP70 is a Rac family guanine nucleotide exchange factor (GEF). It is highly expressed by activated B cells. Following B cell stimulation, SWAP70 has been observed to translocate from the cytoplasm to the nucleus, where it plays a role in class switching, as well as to the membrane, where it associates with the B cell receptor. SWAP70 also plays a role in migration of B cells and other immune cell types including dendritic cells, eosinophils, and mast cells. Mice deficient in both SWAP70 and a related protein, DEF6, develop lupus-like autoimmunity due to misregulation of IRF4 in B cells and T cells leading to increased IL21 production and responsiveness.

Purification and Purity: The antibody was purified by immunogen affinity chromatography.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of SWAP-70 protein.

Extra Notes: Western blot analysis of SWAP-70 expression in COS7 (A), 293T (B), C6 (C), NIH3T3 (D), Hela (E) whole cell lysates.

Bioworld Molecular Weight: ~ 65 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: KIAA0640; Switch-associated protein 70; SWAP-70

Immunogen: Purified recombinant human SWAP70 protein fragments expressed in E.coli.

Conjugate: Unconjugated

Modification: Unmodified