Product Description

Syk (phospho-Y525) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4189-50, BS4189-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Syk (spleen tyrosine kinase) is a 635 amino acid protein that contains one protein kinase domain and two SH2 domains. One of several members of the protein kinase superfamily, Syk functions as a positive effector of B cell antigen receptor (CD79)-stimμlated responses, coupling CD79 with the movement of one calcium ion through one of two phospho-regμlated pathways. Via its ability to influence CD79 activity and to control the movement of calicum through the cell, Syk plays an important role in a variety of cellμlar responses, including differentiation, phagocytosis, proliferation and B cell development. Syk expression is upregμlated in T cell lymphoma, suggesting a possible role for Syk in tumorigenesis. Two isoforms of Syk, designated short and long, exist due to alternative splicing events.

Category: Primary Antibody

Reactivity: Human, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Tyrosine-protein kinase SYK, Spleen tyrosine kinase, p72-Syk, SYK

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human Syk around the phosphorylation site of Tyrosine 525.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-Syk (Y525) polyclonal antibody detects endogenous levels of Syk protein only when phosphorylated at Tyr525.

Molecular Weight: ~ 69 kDa

Pathway: Immune Cell Signaling, B cell receptor signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P43405

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only