Synapsin-1 (phospho Ser553) rabbit pAb - ES8439

Synapsin-1 (phospho Ser553) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8439-50, ES8439-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

Alternate Name: SYN1; Synapsin-1; Brain protein 4.1; Synapsin I

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized phospho-peptide around the phosphorylation site of human Synapsin-1 (phospho Ser553)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 75kD

Human Gene ID: 6853

Human SWISS Prot NO: P17600

Subcellular Location: Cell junction, synapse. Golgi apparatus.

Research Use Only