Product Description

Synphilin-1 (R846) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS2939-50, BS2939-100

Sizes: 50µl, 100µl

Swiss-Prot: Q9Y6H5

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: Synphilin-1 (α-synuclein interacting protein, SNCAIP) is a 919 amino acid protein that associates with α synuclein and promotes the formation of cytosolic inclusions in neuronal cells. The synuclein family members, including α-synuclein and β-synuclein, are predominantly expressed in the brain, where they influence synaptic regulation and neuronal plasticity. Synphilin-1 contains modular protein domains, such as ankyrin-like repeats and a coiled-coil domain.While both α-synuclein and synphilin-1 are coexpressed in Lewy bodies of patients with Parkinson’s disease, only mutations in the gene for α-synuclein have been determined to confer pathogenicity.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Synphilin-1 (R846) polyclonal antibody detects endogenous levels of Synphilin-1 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Synphilin-1 (R846) pAb at 1:500 dilution
Lane 1: 3T3-L1 whole cell lysate (40ug)
Lane 2: C6 whole cell lysate (40ug)
Lane 3: Hela whole cell lysate (40ug)
Lane 4: HEK293T whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of Synphilin-1 (R846) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 100 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Synphilin-1; Sph1; Alpha-synuclein-interacting protein; SNCAIP

Immunogen: Synthetic peptide, corresponding to amino acids 815-867 of Human Synphilin-1.

Conjugate: Unconjugated

Modification: Unmodified