Product Description

Syntenin Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91310-50, BS91310-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O00560(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, ICC IF, IHC FC IP,

All Applications: WB:1:500-1:2,000
ICC/IF:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:200
IP:1:10-1:50

Background: Syntenin-1 (also known as syntenin, syndecan binding protein, melanoma differentiation-associated protein 9 or proTGF-alpha cytoplasmic domain-interacting protein 18) is a protein that binds to the cytoplasmic domains of the syndecans in yeast 2-hybrid screens and other assays. Syntenin-1 contains a tandem repeat of PDZ domains that reacts with the FYA (phe-tyr-ala) carboxy-terminal amino acid sequence of the syndecans. It may function as an adaptor that couples syndecans to cytoskeletal proteins or cytosolic downstream signal-effectors. Syntenin-1 colocalizes and interacts specifically with immature, intracellular forms of proTGF-alpha. It is a human gamma interferon responsive protein. Syntenin-1 contains PSD-95/Discs large/zO-1 (PDZ) domains and associates with the cytoplasmic tail of the IL-5Ralpha. It directly associates with the transcription factor Sox-4. The PDZ proteins PICK1, GRIP, ABP and syntenin-1 bind multiple glutamate receptor subtypes.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: Syntenin polyclonal antibody detects endogenous levels of Syntenin protein.

Bioworld Molecular Weight: 32 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Syntenin on A549 cell using anti-Syntenin antibody at 1/2,000 dilution., ICC staining Syntenin in SH-SY-5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: MDA-9, TACIP18, SDCBP, MDA9, SYCL, MDA-9, MDA9, Melanoma differentiation-associated protein 9, Pro-TGF-alpha cytoplasmic domain-interacting protein 18, Scaffold protein Pbp1, SDCB1, SDCBP, ST1, SYCL, Syndecan binding protein (syntenin), Syndecan binding protein 1, Syndecan-binding protein 1, Syntenin 1, Syntenin-1, TACIP18,

Immunogen: Recombinant protein within human Syntenin aa 1-200.

Conjugate: Unconjugated

Modification: Unmodified