Synuclein-α Monoclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA12048-50, RA12048-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: synuclein alpha (SNCA) Homo sapiens Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016], Reactivity: Human Host: Mouse Applications: WB, IHC-p, IF(paraffin section), ELISA Alternate Names: SNCA, NACP, PARK1, Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP Clonality: Monoclonal Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. Storage: -20°C/1 year Condition: Ascitic fluid containing 0.03% sodium azide, 0.5% BSA, 50% glycerol. Human Gene ID: 6622 Research Use Only