TAB1 (N-term) Mouse Monoclonal Antibody - RA12054

TAB1 (N-term) Mouse Monoclonal Antibody

Size: 50μL, 100μL

Catalogue Numbers: RA12054-50, RA12054-100

Citations, Manuals and MSDS Available upon request.

Background: TGF-beta activated kinase 1 (MAP3K7) binding protein 1 (TAB1) Homo sapiens The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced tr

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Applications: WB

Species Cross-Reactivity: Human

GeneID (Human): 10454

Protein MW (KDa): 55

SWISS: Q15750

Source: Mouse

Research Use Only